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February 11, 2026S S Korsakov Journal of Neurology and Psychiatry0 citations

Migraine: issues of pathogenesis and drug therapy

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TGT S GanshinaAGA V GnezdilovaSLS A Litvinova

Key Points

  • The review aims to clarify the mechanisms behind migraine attacks and explore existing and new therapies.
  • Literature review focusing on migraine pathogenesis mechanisms and drug therapies.
  • Discussion of existing drugs and new compounds for migraine treatment and prevention.
  • Identified key mechanisms involved in migraine including cortical spreading depression and cerebral circulation changes.
  • Highlighted the role of serotonin and calcitonin gene-related peptide in migraine regulation.
  • Outlined current and emerging therapies for effective migraine management.

Abstract

The review discusses the relationship between the mechanisms of migraine pathogenesis, namely, cortical spreading depression, changes in cerebral circulation during a migraine attack and with cortical spreading depression, and the role of serotonin and the calcitonin gene-related peptide in regulating cerebral vessels and their involvement in the emergence of a migraine attack. Drugs used for the treatment and prevention of migraine, as well as new compounds being developed for the treatment and prevention of migraine attacks, are described.

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Cite This Study

Ganshina et al. (2026) studied this question.

synapsesocial.com/papers/698c1c53267fb587c655eb3ehttps://doi.org/10.17116/jnevro202612601145
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