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February 11, 2026Asian Pacific Journal of Cancer Prevention0 citationsOpen Access

Crosstalk between ZEB1 expression and CD163+ Tumor-Associated Macrophages in Muscle-Invasive Urothelial Carcinoma

AAAhmed M. Al‐Hakami SASara Salah Abdel-Hakeem FKFatma M M Kamal

Key Points

This research investigates the relationship between ZEB1 expression and CD163+ tumor-associated macrophages in muscle-invasive urothelial carcinoma.
Analyzed ZEB1 expression levels in muscle-invasive urothelial carcinoma samples.
Assessed the density of CD163+ tumor-associated macrophages (TAMs).
Correlated ZEB1 expression with clinical prognosis.
Elevated ZEB1 expression is linked to increased CD163+ TAM density.
Higher levels of ZEB1 expression correlate with poor clinical outcomes.
ZEB1 shows potential as a biomarker for prognosis in bladder cancer.

Abstract

Elevated ZEB1 expression is strongly associated with poor prognosis in BC and closely correlated with an increased density of CD163+TAMs, further contributing to adverse outcomes. These findings highlight the potential of ZEB1 as a prognostic biomarker and underscore the therapeutic relevance of targeting TAMs in the management of BC.

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