Hawthorn fruit extracts alleviate high-fat diet-induced NAFLD by inhibiting ERK and regulating hepatic purine metabolism

Yuan Zhou; Junjie Qiu; Shanshan Pan; Mengyao Wang; Yifang Dang; Rui Xu; Yong Chen; Xuesong Liu; Jiahui Zhao; Tengfei Xu

doi:10.1039/d5fo03640b

January 1, 2026Food & Function

Hawthorn fruit extracts alleviate high-fat diet-induced NAFLD by inhibiting ERK and regulating hepatic purine metabolism

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Key Points

The aim is to evaluate the effects of hawthorn fruit extracts on non-alcoholic fatty liver disease induced by high-fat diets.
Experiment with high-fat diet-induced models
Administration of hawthorn fruit extracts
Assessment of intrahepatic fat accumulation
Analysis of ERK signaling and hepatic purine metabolism
Hawthorn extracts significantly reduced fat accumulation in the liver
Inhibition of ERK signaling pathway observed
Changes in hepatic purine metabolism noted, contributing to therapeutic outcomes

Implication

This research demonstrates hawthorn fruit extracts alleviate NAFLD in a high-fat diet, suggesting potential therapeutic benefits.

Abstract

Intrahepatic fat accumulation is a characteristic of non-alcoholic fatty liver disease (NAFLD), a chronic metabolic liver disease. Hawthorn fruit is a common fruit in East Asia with fat-reducing properties, while...

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Cite This Study

Zhou et al. (2026) studied this question.

synapsesocial.com/papers/698c1ca1267fb587c655f3d4 https://doi.org/10.1039/d5fo03640b

View Full Paper

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Hawthorn fruit extracts alleviate high-fat diet-induced NAFLD by inhibiting ERK and regulating hepatic purine metabolism

Key Points

Implication

Abstract

Discussion

Cite This Study

Hawthorn fruit extracts alleviate high-fat diet-induced NAFLD by inhibiting ERK and regulating hepatic purine metabolism

Key Points

Implication

Abstract

Discussion

Cite This Study

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