The hawthorn ( Crataegus pinnatifida ) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway

Xue Han; Yuchen Fang; H J Wang; Anni Fu; Jianfeng Sun; Zhiqiang Wang; Лей Ма

doi:10.1039/d6fo01304j

January 1, 2026Food & Function

The hawthorn ( Crataegus pinnatifida ) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway

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Key Points

This research aims to clarify the therapeutic mechanisms of hawthorn procyanidin extract against NAFLD.
Mice were treated with hawthorn procyanidin extract to evaluate its effects on liver health.
Gut microbiota and bile acid profiles were analyzed post-treatment to assess changes.
The FXR pathway was monitored to understand the regulation mechanisms involved.
Hawthorn procyanidin extract significantly reduced liver fat accumulation in treated mice compared to controls.
Alterations in gut microbiota composition were observed, leading to improved bile acid profiles.
Regulation of the FXR pathway was linked to the protective effects on liver function.

Implication

Shows attenuation of NAFLD in mice using hawthorn procyanidin extract, suggesting a novel intervention.

Abstract

Hawthorn procyanidin extract (HPC) is one of natural plant-derived polyphenol with lipid-lowering and liver-protective properties, while its therapeutic mechanisms against nonalcoholic fatty liver disease (NAFLD) require further clarification.

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6a323b21d50b63ecad205d16 https://doi.org/10.1039/d6fo01304j

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The hawthorn ( Crataegus pinnatifida ) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

The hawthorn ( Crataegus pinnatifida ) procyanidin extract attenuates nonalcoholic fatty liver disease in mice via remodeling the bile acid profile driven by gut microbiota and regulating the FXR pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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