What question did this study set out to answer?

The aim is to analyze where disease genes operate in the body and the implications for drug development.

February 11, 2026Genome biologyOpen Access

The gene expression landscape of disease genes

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This research reveals gene expression patterns linked to diseases in various tissues, implying novel insights for drug development.

The aim is to analyze where disease genes operate in the body and the implications for drug development.
Integrated genome-wide association study summary statistics with gene prioritisation results.
Utilized RNA-seq data from 46 tissues and 204 cell types.
Analyzed gene expression in relation to 11 major diseases and cancers.
Identified technical and biological factors influencing gene expression.
Disease genes showed higher and more specific expression than control genes in relevant tissues.
Elevated expression was found in some tissues with no prior links to the diseases.
Identified tissue-disease pairs associated with increased odds of drug development inclusion.
Functional follow-up studies can be supported using this framework.

García‐González et al. (2026) studied this question.

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