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This research aims to understand how the Legionella effector SidG alters host cytoskeleton dynamics during infection.

February 11, 2026PLoS PathogensOpen Access

Legionella effector protein SidG disrupts host cytoskeleton via targeting Arp2/3 complex

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This research aims to understand how the Legionella effector SidG alters host cytoskeleton dynamics during infection.
Characterization of SidG and its interaction with the GTPase Rac1.
Exploration of SidG's effects on the Arp2/3 complex involved in actin nucleation.
Investigation of mechanisms by which SidG disrupts cytoskeletal architecture.
SidG disrupts cytoskeletal architecture in a Rac1- and Arp2/3-dependent manner.
The interaction of SidG with Rac1 is crucial for its function.
SidG promotes efficient bacterial invasion in a Cys-His-Asp motif-dependent way.

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Reveals how Legionella pneumophila alters cell structure by exploiting host GTPase Rac1.

Liu et al. (2026) studied this question.

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