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February 11, 2026PLoS ONEOpen Access

Association of VDR gene polymorphisms with prediabetes and Type 2 diabetes mellitus in a sample of the Iranian population

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Authors

DSDorsa SalabatNPNekoo PanahiNFNoushin Fahimfar

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Overview

Multicenter analysis reveals VDR gene polymorphisms align with prediabetes and diabetes risk in Iranians, indicating personalized management strategies.

Key Points

  • This study aims to explore the link between VDR gene polymorphisms and type 2 diabetes risk in the Iranian population.
  • Analyzed data from 976 participants in the Iranian Multicenter Osteoporosis Study.
  • Genotyped five VDR polymorphisms (ApaI, TaqI, EcoRV, FokI, BsmI).
  • Employed logistic regression to assess associations with prediabetes and diabetes.
  • The ApaI polymorphism showed a significant link to prediabetes and diabetes risk.
  • Individuals with the CC genotype had a 66% higher risk of developing these conditions.
  • Carrying at least one A allele decreased the likelihood of developing prediabetes or diabetes by 35%.

Cite This Study

Salabat et al. (2026) studied this question.

synapsesocial.com/papers/698c1cd3267fb587c655f97ehttps://doi.org/10.1371/journal.pone.0339758
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