What question did this study set out to answer?

This study aims to explore the relationship between polybrominated diphenyl ethers (PBDEs) and biological aging.

February 11, 2026GeoHealthOpen Access

Associations Between Polybrominated Diphenyl Ethers and Biological Aging in NHANES 2005–2010 and 2015–2016

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Cross-sectional analysis examines PBDEs' link to biological aging, suggesting potential health implications.

This study aims to explore the relationship between polybrominated diphenyl ethers (PBDEs) and biological aging.
Analyzed cross-sectional data from NHANES 2005–2010 and 2015–2016 with 6,091 subjects.
Measured serum PBDE concentrations using automated liquid-liquid extraction.
Assessed biological aging using homeostatic dysregulation (HD), Klemera-Doubal method (KDM), phenoAge (PA), and allostatic load (AL).
Used weighted multivariate linear regression models, restricted cubic spline, weighted quantile sum regression, and Quantile G-computation analysis to evaluate associations.
Detected positive associations between several PBDEs (including PBDE47, PBDE99) and biological aging metrics.
PBDE100 showed a significant association with allostatic load (β > 0, P < 0.050).
Mixed PBDE exposure correlated positively with biological aging indicators, highlighting PBDE99, PBDE47, and PBDE85 as key contributors.

Chen et al. (2026) studied this question.

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