Key result
Baseline preadolescent fMRI activation patterns correlate slightly with behavioral performance on cognitive tasks.
Why the study?
To track neurodevelopment and identify individual differences in brain function by establishing baseline functional MRI activation patterns in preadolescents.
This study establishes the preadolescent brain function baseline using fMRI tasks, guiding interpretation of cross-sectional analyses and enabling future longitudinal investigation.
Establishes preadolescent fMRI baseline; extends adolescent data but leaves causal and longitudinal questions open.
The Adolescent Brain Cognitive Development (ABCD) Study® is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N = 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N = 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N = 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.
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Chaarani et al. (2021) studied this question. Baseline brain function in preadolescents showed robust fMRI activation patterns correlating slightly with individual behavioral performance on cognitive tasks.
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