Key result
Systemic injection of recombinant AAV8 did not effectively transduce lower motor neurons but successfully labeled sensory fibers in dorsal root ganglia in neonatal mice.
Why the study?
Does systemic injection of rAAV8 transduce lower motor neurons in neonatal mice?
Population
Neonatal mice on postnatal day 1
Design
Preclinical
Follow-up
14 days
Authors
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Caution against systemic rAAV8 for LMN targeting in neonates; leaves open its potential for sensory fiber gene therapy in preclinical models.
Does systemic injection of rAAV8 transduce lower motor neurons in neonatal mice?
Systemic injection of rAAV8 in neonatal mice is ineffective for targeting lower motor neurons but effectively transduces dorsal root ganglia, suggesting potential for targeting sensory pathways.
Foust et al. (2007) studied this question. Systemic injection of recombinant AAV8 did not effectively transduce lower motor neurons but successfully labeled sensory fibers in dorsal root ganglia in neonatal mice.
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