What question did this study set out to answer?

To investigate the gene expression profile of thyroid cancer stem-like cells and their tumor interactions.

February 12, 2026Discover Oncology0 citationsOpen Access

JAG1 expression in papillary thyroid cancer stem-like cells predicts poor prognosis and implicates angiogenesis

RYRiho Yoshida-MinatoKanazawa Medical University THTetsuhiro HorieKanazawa Medical University MAMitsuharu AgaKanazawa Medical University

Key Points

To investigate the gene expression profile of thyroid cancer stem-like cells and their tumor interactions.
Analyzed gene expression profiles of thyroid cancer stem-like cells
Examined the role of JAG1 in tumor progression
Assessed interactions between cancer stem-like cells and tumor microenvironment
JAG1 expression correlates with poor prognosis in papillary thyroid cancer
Thyroid cancer stem-like cells exhibit increased angiogenic potential
Interactions with tumor tissue cells influence cancer progression

Abstract

This study provides new insights into the gene expression profile of thyroid CSC-like cells and their interactions with cells constituting tumor tissues.

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