Effects of Lactiplantibacillus plantarum on moderate dyslipidemia before medication involving gut microbiota and host genetics

Key Points

• To assess the impact of Lactiplantibacillus plantarum on cholesterol levels in individuals with moderate dyslipidemia while considering gut microbiota and host genetics.
• Conducted a 12-week trial with 136 participants suffering from moderate dyslipidemia.
• Random assignment to Lactiplantibacillus plantarum supplementation or placebo.
• Analysis of LDL-C and total cholesterol levels pre- and post-intervention.
• Utilized machine learning models to evaluate the relationship between microbiota changes and lipid reductions.
• LP supplementation resulted in significant reductions in LDL-C (-0.118 mmol/L) and total cholesterol (-0.163 mmol/L) compared to placebo.
• Participants with lower genetic risk scores showed substantial LDL-C reductions (-0.749 ± 0.632 mmol/L) and total cholesterol reductions (-1.306 ± 0.436 mmol/L).
• Post-intervention differences in gut microbial composition correlated with lipid changes, especially in bile acids.