Researchers demonstrate efficient anti-Markovnikov hydroalkoxylation in alkenes using diaryl diselenides, suggesting a new catalytic approach.
The development of general anti-Markovnikov hydroalkoxylation methods remains challenging due to competing alkene oxidation and photocatalyst-alcohol compatibility issues. Herein, diaryl diselenides serve as efficient electron-shuttle catalysts for visible-light-driven anti-Markovnikov hydroalkoxylation in combination with TPT⁺BF₄⁻. A broad range of aryl- and alkyl-substituted alkenes and diverse alcohols are accommodated, affording products up to 97% yield. Mechanistic studies reveal a diselenide-mediated, multistep electron-shuttle pathway that enables mild and selective transformations.
No takes yet. Share an insight, caveat, or question.
Jang et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: