What question did this study set out to answer?

The aim is to assess the long-term effectiveness of vagus nerve stimulation on disabling seizures in adults with drug-resistant epilepsy.

February 12, 2026Neurological SciencesOpen Access

The impact of vagus nerve stimulation on the most disabling seizures: A retrospective study in adults with drug-resistant epilepsy

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Retrospective analysis shows vagus nerve stimulation reduces severe seizures in adults with drug-resistant epilepsy, suggesting earlier intervention.

The aim is to assess the long-term effectiveness of vagus nerve stimulation on disabling seizures in adults with drug-resistant epilepsy.
Retrospective, single-center study of adults with drug-resistant epilepsy who received vagus nerve stimulation.
Follow-up data collected pre-implantation, at 12 months, and last follow-up.
Outcomes measured include seizure frequency, severity, and battery replacement needs.
54% of subjects showed reduced overall seizure frequency at last follow-up.
75% to 80.6% of individuals with tonic-clonic seizures reported frequency reduction.
Over 70% of drop attacks improved, with 21.8% experiencing complete resolution.

Scarabello et al. (2026) studied this question.

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Retrospective analysis shows vagus nerve stimulation reduces severe seizures in adults with drug-resistant epilepsy, suggesting earlier intervention.