What is the clinical evidence from this study?

Study design: Observational. Population: Atherosclerosis (n=164). Intervention: MBL non-A infection-susceptibility alleles vs. MBL A allele homozygotes. Primary outcome: Carotid plaque area (CPA) (p=0.009).

What question did this study set out to answer?

This research aims to explore the relationship between MBL infection-susceptibility alleles and carotid plaque area.

February 12, 2026Journal of Investigative Medicine

Infection-Susceptibility Alleles of Mannose-Binding Lectin are Associated with Increased Carotid Plaque Area

Q: What are the key findings of this study?

Presence of at least one MBL non-A infection-susceptibility allele was significantly associated with increased carotid plaque area compared to MBL A allele homozygotes (P=0.009).

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Key result

MBL non-A infection-susceptibility alleles linked to increased carotid plaque area vs A homozygotes.

P=0.009
n=164

Why the study?

Is the presence of MBL non-A infection-susceptibility alleles associated with increased carotid plaque area?

Key Points

This research aims to explore the relationship between MBL infection-susceptibility alleles and carotid plaque area.
Measured carotid plaque area using 2-dimensional ultrasound in 164 subjects.
Genotyped subjects for MBL codons 52, 54, and 57.
Assessed traditional atherosclerosis risk factors including age, smoking, hypertension, and hyperlipidemia.
Applied ANOVA to analyze CA and test associations with MBL genotype.
Significant association between carotid plaque area and MBL genotype was found (P<0.05).
Regression analysis indicated a stronger association of MBL non-A alleles with higher carotid plaque area (P=0.009).
Subjects with at least one MBL non-A allele exhibited significantly greater carotid plaque area compared to those homozygous for the MBL A allele.

Study Design

Type

Observational (n=164)

Structured PICO

Is the presence of MBL non-A infection-susceptibility alleles associated with increased carotid plaque area?

Population

164 subjects assessed for mannose-binding lectin (MBL) genotype and carotid plaque area.

Exposure

Presence of at least one MBL non-A 'infection-susceptibility' allele (codons 52, 54, and 57)

Comparator

Homozygous for the MBL A allele

Outcome

Carotid plaque area (CPA) measured with 2-dimensional ultrasoundsurrogate

Main Result

p-value: p=0.009

Authors

RHRA HegeleWestern University MBMatthew R. BanBroad Institute CACarol M. AndersonAllegheny College

Discussion

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Implication

Infection-susceptibility alleles of MBL are associated with increased carotid plaque area, suggesting a genetic determinant for interindividual differences in atherosclerosis risk.

Cite This Study

Hegele et al. (2000) conducted an observational in Atherosclerosis (n=164). MBL non-A infection-susceptibility alleles vs. MBL A allele homozygotes was evaluated on Carotid plaque area (CPA) (p=0.009). Presence of at least one MBL non-A infection-susceptibility allele was significantly associated with increased carotid plaque area compared to MBL A allele homozygotes (P=0.009).

synapsesocial.com/papers/698d6d795be6419ac0d52627 https://doi.org/10.1177/108155890004800307

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Implication

Infection-susceptibility alleles of MBL are associated with increased carotid plaque area, suggesting a genetic determinant for interindividual differences in atherosclerosis risk.

Infection-Susceptibility Alleles of Mannose-Binding Lectin are Associated with Increased Carotid Plaque Area

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Infection-Susceptibility Alleles of Mannose-Binding Lectin are Associated with Increased Carotid Plaque Area

Key Points

Study Design

Structured PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Also Consider