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February 12, 2026ChemistrySelectOpen Access

Efficient α‐Selective Chlorination of Meta ‐ and Ortho ‐Substituted Phenylacetic Acids

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To develop an efficient method for the alpha-chlorination of meta- and ortho-substituted phenylacetic acids using trichloroisocyanuric acid.
Utilized trichloroisocyanuric acid (TCCA) with catalytic PCl3
Conducted chlorination under solvent-free conditions
Tested a selection of 13 ortho and meta-substituted phenylacetic acids
Successfully chlorinated substrates at the benzylic position without competing electrophilic chlorination
Identified two outliers that did not chlorinate as expected
Showed potential for synthesizing alpha-chlorophenylacetic acids as synthons for pharmaceuticals, including clopidogrel.

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Implication

This research demonstrates selective alpha-chlorination in ortho and meta-substituted phenylacetic acids, indicating a novel method for pharmaceutical synthesis.

Cite This Study

Giraudo et al. (2026) studied this question.

synapsesocial.com/papers/698d6d8c5be6419ac0d52886 https://doi.org/10.1002/slct.202506551

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Implication

This research demonstrates selective alpha-chlorination in ortho and meta-substituted phenylacetic acids, indicating a novel method for pharmaceutical synthesis.

Efficient α‐Selective Chlorination of Meta ‐ and Ortho ‐Substituted Phenylacetic Acids

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Implication

Cite This Study

Efficient α‐Selective Chlorination of Meta ‐ and Ortho ‐Substituted Phenylacetic Acids

Key Points

Discussion

Implication

Cite This Study

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