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This study aims to evaluate the long-term effects of regenerative endodontic treatment in immature permanent teeth with pulp necrosis.

February 12, 2026ChildrenOpen Access

Regenerative Endodontic Treatment in Permanent Incisors: Two Case Reports with 6 Years of Follow-Up

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Case reports demonstrate effective healing in necrotic immature teeth, suggesting RET's reliability and durability.

This study aims to evaluate the long-term effects of regenerative endodontic treatment in immature permanent teeth with pulp necrosis.
Reported two pediatric cases involving regenerative treatment on three permanent incisors.
Utilized triple antibiotic paste and mineral trioxide aggregate in one case; calcium hydroxide and Biodentine in the other.
Conducted clinical and radiographic evaluations, including cone beam computed tomography.
Complete symptom resolution and periapical healing observed in all treated teeth.
Development of a calcified apical barrier noted after treatment.
Outcomes remained stable over six years of follow-up.

Biedma-Perea et al. (2026) studied this question.

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