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Identifying metabolic gene signatures predicts graft rejection in kidney transplants, suggesting new biomarker potential.
We identified a distinct metabolic gene signature capable of predicting kidney transplant rejection. The downregulation of DPP4 with the upregulation of PPARG and INSR suggests that metabolic reprogramming and loss of homeostasis are hallmarks of immune-mediated graft failure.
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Casale et al. (2026) studied this question.
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