Akalu et al. report TBK1 deficiency leads to severe viral encephalitis in affected individuals, indicating a need for vigilant care.
Akalu et al. report new and long-term follow-up cases of human TBK1 deficiency, revealing that, beyond systemic autoinflammation, affected individuals are also vulnerable to severe viral encephalitis. Their findings highlight the dual nature of TBK1 deficiency—combining autoinflammatory disease with impaired antiviral defense—and emphasize the need for antiviral vigilance in care.
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Akalu et al. (2026) studied this question.
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