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This research aims to elucidate the evolutionary processes and genetic landscapes of the Yugur and Uyghur populations.

February 12, 2026Briefings in BioinformaticsOpen Access

Divergent Eurasian ancestry and local adaptation shape the genetic landscapes of the Yugur and Uyghur

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This research aims to elucidate the evolutionary processes and genetic landscapes of the Yugur and Uyghur populations.
Generated high-coverage whole-genome sequences for the Yugur.
Compared genomic data of Yugur with Uyghur to analyze demographic histories and ancestry profiles.
Used modeling to identify admixture events in Gansu and Xinjiang regions.
Conducted functional enrichment analyses to explore immune and metabolic pathways.
Yugur retain predominantly East Eurasian ancestry (~90%), while Uyghur show a near-equal mix of East and West Eurasian ancestry.
Distinct admixture events were identified, revealing reduced genetic continuity between populations.
Selection signals indicate strong positive selection on the FADS locus in Yugur linked to lipid metabolism, and greater selection intensity at PPARA in Uyghur.
Functional analyses indicate overlapping immune and metabolic pathways shaped by demographic history.

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Genomic analysis uncovers distinct ancestry and adaptation patterns in the Yugur and Uyghur, indicating evolutionary divergence.

Yu et al. (2026) studied this question.

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