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February 12, 2026PNAS NexusOpen Access

In vivo imaging of metabolic heterogeneity across three endpoints relevant to aggressive breast cancer

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In vivo imaging reveals metabolic heterogeneity in triple-negative breast cancer, suggesting new treatment strategies.

This research aims to investigate the metabolic heterogeneity in triple-negative breast cancer (TNBC) using a novel imaging technique.
Developed an in vivo microscope for measuring glucose, fatty acids, and oxidative phosphorylation.
Performed widefield imaging across a 5 mm x 5 mm tumor area to assess metabolic distribution.
Analyzed murine models of TNBC and normal mammary tissues for comparative metabolic analysis.
Normal mammary tissues showed consistent reliance on oxidative metabolism.
Tumors exhibited predominantly glycolytic behavior with diverse nutrient uptake.
Metabolic preferences within tumors revealed regions with distinct nutrient uses, including glucose and fatty acids.

D’Agostino et al. (2026) studied this question.

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