What question did this study set out to answer?

Identify perinatal risk factors for early acute kidney injury (AKI) and assess its long-term neurodevelopmental impact.

February 12, 2026Pediatric NephrologyOpen Access

Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants

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Authors

IBIsadora BeghettiAzienda USL di Bologna EBEttore BenvenutiUniversity of Bologna LLLivia LucchiniAzienda Ospedaliera Sant'Andrea

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Implication

Retrospective cohort analysis examines perinatal risk factors affecting AKI and neurodevelopment in very preterm infants, indicating critical implications for care.

Key Points

Identify perinatal risk factors for early acute kidney injury (AKI) and assess its long-term neurodevelopmental impact.
Retrospective cohort study of 339 preterm infants born < 32 weeks gestational age or < 1500 g
AKI defined by serum creatinine or urine output criteria
Examined gestational age, birth weight, perinatal factors including NSAIDs and inotropes
Used regression analyses to identify risk factors and impacts of AKI on neurodevelopment.
AKI incidence was 42% using serum creatinine criteria and 7% using urine output criteria
Elbw infants, exposure to NSAIDs, and inotropes were significant risk factors for AKI
Maternal hypertension and female sex showed protective effects
AKI-UO linked to lower growth z-scores and longer hospital stays
AKI's impact on neurodevelopment diminished after adjusting for comorbidities.

Cite This Study

Beghetti et al. (2026) studied this question.

synapsesocial.com/papers/698d6dd15be6419ac0d530e8 https://doi.org/10.1007/s00467-026-07170-4

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Implication

Retrospective cohort analysis examines perinatal risk factors affecting AKI and neurodevelopment in very preterm infants, indicating critical implications for care.

Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants

Discussion

Member takes

Implication

Key Points

Cite This Study

Perinatal risk factors and 2-year neurodevelopmental outcome of early acute kidney injury in very preterm and very low birth weight infants

Discussion

Member takes

Implication

Key Points

Cite This Study

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