Abstract A remote, motivational interviewing–informed intervention using self-administered point-of-care urine tenofovir testing improved long-term pre-exposure prophylaxis (PrEP) adherence among young U.S. men-who-have-sex-with-men in a pilot randomized trial. Participants increased hair tenofovir levels by one to two tablets weekly, with high feasibility and acceptability, supporting further implementation.
Spinelli et al. (2026) studied this question.