Efficient synthesis of α-trifluoromethyl-β-lactams in nitrones using copper catalysis, suggesting useful methods for organic chemistry.
An efficient protocol for synthesizing α-trifluoromethyl-β-lactams through copper-catalyzed Kinugasa reaction of nitrones with in situ generated 3,3,3-trifluoropropyne. The reaction proceeds through generations the Cu(I) acetylide species, followed by a regioselective...
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Chen et al. (2025) studied this question.
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