Model analyzes viral dynamics and immunological factors affecting HIV transmission, suggesting implications for treatment strategies.
This study investigates a viral infection dynamics model that incorporates cell-to-cell transmission, latency, and a generalized humoral immune response. We rigorously establish the existence and uniqueness, boundedness, and asymptotic smoothness of the model’s semi-flow solution, discuss the local and global stability of equilibria, and identify two key thresholds ( R₀ R 0 and R₁ R 1 ) that govern the model’s global dynamics. To demonstrate that HIV transmission may indeed exhibit the described dynamic behaviours, we fit viral load data from two HIV cases, revealing distinct immune states in the two patients.
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Ding et al. (2026) studied this question.
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