This review highlights 1,2-difunctionalization reactions involving 4-cyanopyridines, indicating promising synthetic applications.
Due to producing persistent pyridyl radicals, 4-cyanopyridine is widely used in the decyanative pyridylation reactions towards C4-functionalized pyridine derivatives. This review highlights 1,2-difunctionalization reactions involving 4-cyanopyridine.
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Raymand et al. (2026) studied this question.
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