Prognostic Value of Elevated miR‐502‐3p in Patients With Post‐Stroke Cognitive Impairment

Background Post‐stroke cognitive impairment (PSCI) is a common complication following a stroke. Recent findings highlight the role of miR‐502‐3p in both vascular and neurodegenerative diseases. However, the role in PSCI remains uncovered. Objective This study emphasized the differential expression of miR‐502‐3p and subsequently evaluated the predictive value of miR‐502‐3p expression levels for PSCI. Materials and methods The study subjects included 112 patients with PSCI and 161 individuals with post‐stroke cognitive normality. The relative expression of miR‐502‐3p was calculated by qPCR, while its predictive value for PSCI was assessed via ROC curve. Pearson's correlation coefficient was utilized to analyze the correlation between serum miR‐502p‐3p levels and PSCI. Multivariate logistic regression was used to identify risk factors of PSCI. Results Serum miR‐502‐3p was identified as significantly elevated in the PSCI group. The area under the ROC curve was 0.850, with a sensitivity of 76.79% and a specificity of 77.64%. The miR‐502‐3p level was positively correlated with both NIHSS and mRS scores. In addition, a negative correlation was observed between the miR‐502‐3p level and MoCA score. Elevated miR‐502‐3p and hypertension were identified as independent risk factors for PSCI. Conclusion Significantly elevated serum miR‐502‐3p was a promising biomarker for the onset of PSCI. Elevated miR‐502‐3p and hypertension were independent risk factors for PSCI.