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February 12, 2026Drug and Chemical Toxicology

DNA damage induced by fungicides triadimefon, triadimenol, and their mixture in human lymphocytes: cytogenotoxicity and computational analysis of metabolic pathways

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Authors

AFAmanda Silva FernandesASA. L. Balduino de SouzaMSMarcelino Benvindo de Souza

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Overview

Investigates cytogenotoxic effects of triazole fungicides in human lymphocytes, suggesting risks to genomic stability.

Key Points

  • The aim is to evaluate the cytogenotoxic effects of the fungicides triadimefon and triadimenol on human lymphocytes.
  • Tested triadimefon and triadimenol at various concentrations on human lymphocytes
  • Used trypan blue exclusion test and comet assay to assess cell viability and DNA damage
  • Employed in silico tools to analyze metabolic pathways and gene expression predictions.
  • Exposure led to an increase in DNA strand breaks in lymphocytes for both compounds
  • No impact on cell viability was observed at the tested concentrations
  • In silico analysis predicted interactions with cytochrome P450 isoforms and effects on gene expression related to several health risks.

Cite This Study

Fernandes et al. (2026) studied this question.

synapsesocial.com/papers/698d6e3c5be6419ac0d53b68https://doi.org/10.1080/01480545.2026.2626753
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