Observational research identifies autoaggregation as a mechanism of carbapenem tolerance in Klebsiella, indicating significant implications for treatment strategies.
This study identified mrkH-linked autoaggregation as a novel mechanism of carbapenem tolerance in Klebsiella isolates. Overall, the findings underscore the role of multicellular behaviours in antibiotic resilience and highlight the potential clinical relevance of non-carbapenemase-mediated tolerance mechanisms.
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Yamanaka et al. (2026) studied this question.
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