Unraveling the emergence and mechanisms of carbapenema resistance in Klebsiella pneumoniae

The emergence and rapid spread of carbapene-resistant klebsiella pneumoniae has become a severe clinical concern. The acquisition of carbapenemase enzymes is a common mechanism contributing to resistance. Alterations in outer membrane permeability and upregulation of efflux pumps, have also been implicated. In addition, approaches to combat CRKP infections may involve the use of combination therapy, development of new antibiotics, scientific prevention and phase therapy which targets multiple bacterial mechanisms simultaneously. This review aims to look into the drug resistant mechanism and some possible therapies of anti-CRKP infection, provided valuable information on the mechanism of Carbapenem Resistance, enhancing the progress of novel strategies targeting CRKP.