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February 12, 2026Scientific ReportsOpen Access

Positive ascites cytology in interval debulking surgery predicts poor outcomes of advanced epithelial ovarian cancer achieving complete tumor resection

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Authors

MYMarina YoshikawaMYMasato YoshiharaRERyo Emoto

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Overview

Positive ascites cytology predicts poor survival outcomes in advanced ovarian cancer after surgery, highlighting prognostic implications.

Key Points

  • The study aims to evaluate the prognostic significance of positive ascites cytology after neoadjuvant chemotherapy and complete tumor resection in ovarian cancer patients.
  • Analyzed data from 4944 patients with advanced ovarian cancer
  • Compared outcomes between primary debulking surgery (PDS) and neoadjuvant chemotherapy followed by interval debulking surgery (NAC-IDS)
  • Conducted Kaplan-Meier, univariate, and multivariate analyses to assess prognosis.
  • Positive ascites cytology correlated with higher recurrence (OR = 2.412) and mortality (OR = 2.025) at 5 years,
  • NAC-IDS patients had greater risks for progression-free survival (HR = 2.003) and overall survival (HR = 3.259) compared to PDS.
  • Interaction effects indicated a higher mortality risk in NAC patients with positive ascites cytology (OR of NAC-IDS = 3.722).

Cite This Study

Yoshikawa et al. (2026) studied this question.

synapsesocial.com/papers/698d6e5a5be6419ac0d54046https://doi.org/10.1038/s41598-026-37664-y
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer2021 · 17 citations
  2. 2Neoadjuvant Chemotherapy or Primary Surgery in Stage IIIC or IV Ovarian Cancer2010 · 2,558 citations
  3. 3Heterotypic CAF-tumor spheroids promote early peritoneal metastasis of ovarian cancer2019 · 265 citations
  4. 4Trends in Primary Treatment and Median Survival Among Women With Advanced-Stage Epithelial Ovarian Cancer in the US From 2004 to 20162020 · 55 citations