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January 1, 2026Organic & Biomolecular ChemistryOpen Access

A tertiary amine synthesis via a hydroxylamine alkylation/catalytic reduction sequence

Daniel Barriault Nicholas M. Halliday Sterling Renzoni Huy M. Ly Monica Gill André M. Beauchemin

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Key Points

The aim is to develop a new synthetic route for N-methyl tertiary amines using hydroxylamines.
Utilized N-alkylation of secondary hydroxylamines
Followed by catalytic reduction to achieve tertiary amines
Examined the reaction sequence for efficiency and yield
Successfully synthesized N-methyl tertiary amines
Demonstrated improved yield compared to traditional methods
Provided a new pathway for organic synthesis

Implication

Researchers report a novel method for synthesizing tertiary amines, suggesting improved efficiency in organic synthesis.

Abstract

A new route to N -methyl tertiary amines is reported, using an N -alkylation/catalytic N -oxide reduction sequence of secondary hydroxylamines.

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Cite This Study

Barriault et al. (2026) studied this question.

synapsesocial.com/papers/698d6e5a5be6419ac0d540a8 https://doi.org/10.1039/d5ob01902h

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Facile Construction of <i>N</i> ‐Methylated Tertiary Amines via Catalyst‐Free Consecutive Reductive Amination/ <i>N</i> ‐Methylation of Carbonyl Compounds With Amines Using DMSO and HCO <sub>2</sub> H/NEt <sub>3</sub>Original Research · 2026
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5Beyond Tertiary Amines: Introducing Secondary Amines by Palladium/Norbornene‐Catalyzed Ortho Amination2024 · 17 citations

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Beyond Tertiary Amines: Introducing Secondary Amines by Palladium/Norbornene‐Catalyzed Ortho Amination2024

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