Microfluidic-Based Intra-Articular Sustained Release of Triamcinolone Acetonide Microsphere-Gel Composite System

Yanan Zhu; Yongqi Lv; Jiaqi Xu; Yingshu Feng; Caleb Kesse Firempong; Runfeng Wang; Haibing He; Guoqing Zhang; Hongfei Liu

doi:10.1080/03639045.2026.2629611

February 10, 2026Drug Development and Industrial Pharmacy

Microfluidic-Based Intra-Articular Sustained Release of Triamcinolone Acetonide Microsphere-Gel Composite System

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Key Points

To evaluate the effectiveness of a microsphere-gel composite system for local drug delivery in osteoarthritis treatment.
Developed a triamcinolone acetonide microsphere-gel composite using microfluidic techniques.
Assessed drug release kinetics in vitro.
Evaluated systemic exposure and effectiveness in a preclinical model.
The composite system significantly reduced systemic exposure compared to traditional delivery methods.
Prolonged local release of triamcinolone acetonide was observed.
Demonstrated a positive impact on osteoarthritis treatment outcomes.

Implication

Microsphere-gel composite system effectively delivers triamcinolone acetonide in osteoarthritis, suggesting reduced side effects.

Abstract

The TA@PCL@CLHA microsphere-gel composite provides an effective local drug delivery system with minimized systemic exposure, offering a promising strategy for OA treatment.

Discussion

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Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/698d6e925be6419ac0d54618 https://doi.org/10.1080/03639045.2026.2629611

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Microfluidic-Based Intra-Articular Sustained Release of Triamcinolone Acetonide Microsphere-Gel Composite System

Key Points

Implication

Abstract

Discussion

Cite This Study

Microfluidic-Based Intra-Articular Sustained Release of Triamcinolone Acetonide Microsphere-Gel Composite System

Key Points

Implication

Abstract

Discussion

Cite This Study

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