Key result
Early glucocorticoids for hypereosinophilia prevent recurrent stroke and ICH in two patients.
Why the study?
Patients with hypereosinophilic syndrome experience thrombotic events such as ischemic stroke, but the simultaneous occurrence of ischemic stroke and intracerebral hemorrhage in this population has rarely been reported.
Do glucocorticoids prevent additional ischemic stroke or ICH in patients with hypereosinophilic syndrome?
Case Report (n=2)
Do glucocorticoids prevent additional ischemic stroke or ICH in patients with hypereosinophilic syndrome?
Patients with hypereosinophilic syndrome can experience simultaneous ischemic and hemorrhagic strokes, emphasizing the need for early control of eosinophilia with glucocorticoids to reduce cerebrovascular complications.
May support early glucocorticoid control of eosinophilia to avert recurrent strokes in hypereosinophilic syndrome; hypothesis-generating from case reports only.
Patients with hypereosinophilic syndrome (HES) suffer from thrombotic events including ischemic stroke. Simultaneous occurrence of stroke and intracerebral hemorrhage (ICH) in such patients have rarely been reported. Here, we describe two patients with HES who suffered from ischemic stroke complicated by ICH. In case 1, we used a recombinant tissue plasminogen activator for acute ischemic stroke without treating hypereosinophilia; consequently, ICH occurred. In case 2, the patient had an ischemic stroke and ICH upon admission. In both cases, we used glucocorticoids to control hypereosinophilia, and no additional ischemic stroke or ICH occurrence was observed. These cases suggest that patients with HES can experience both ischemic and hemorrhagic strokes simultaneously and emphasize the importance of early control of eosinophilia to reduce the risk of cerebrovascular complications.
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Hidaka et al. (2026) conducted a case report in Hypereosinophilic syndrome with ischemic stroke and intracerebral hemorrhage (n=2). Glucocorticoids was evaluated on Additional ischemic stroke or intracerebral hemorrhage occurrence. Early control of eosinophilia using glucocorticoids in two patients with hypereosinophilic syndrome prevented additional ischemic stroke or intracerebral hemorrhage occurrences.
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