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February 12, 2026PathogensOpen Access

Persistent and Long-Term Infectivity of Dengue Virus in Mosquito Cells Revealed Reduced Replication in Vector Host and Human Endothelial Cells

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Authors

SBSwarnendu BasakMBMd BayzidGNGirish Neelakanta

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Overview

Reveals reduced dengue virus replication in vector host and human endothelial cells, indicating implications for long-term infectivity.

Key Points

  • To investigate the replication and survival of dengue virus in vector host cells over time.
  • Infection of Aedes albopictus C6/36 mosquito cells with DENV2.
  • Measurement of viral loads in cell culture supernatants at multiple time points.
  • Assessment of viral replication kinetics in naive mosquito and human endothelial cells.
  • Isolation and analysis of extracellular vesicles from infected cultures.
  • DENV2 viral titers and infectivity decreased from days 19 to 175 post-infection.
  • Persistent viral replication competence observed in mosquito cells over the study period.
  • Extracellular vesicles increased in concentration but showed a decline in viral loads over time.
  • Viral membrane proteins were detected only in early timepoints, indicating changes in EV content.

Cite This Study

Basak et al. (2026) studied this question.

synapsesocial.com/papers/698d6eca5be6419ac0d54ac5https://doi.org/10.3390/pathogens15020202
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