Retrospective analysis shows lower interhemispheric coherence in adults with severe epilepsy compared to those without, suggesting significant differences in brain connectivity.
Key Points
This research aims to compare interhemispheric coherence in adults with severe generalized epilepsy and those without epilepsy.
Retrospective analysis of EEG data from patients with severe non-lesional generalized epilepsy who had corpus callosotomy.
EEG data during non-rapid eye movement sleep were collected from patients in both groups.
Interhemispheric coherence was evaluated across various frequency bands using eight pairs of electrodes.
Interhemispheric coherence values in multiple frequency bands including delta, theta, alpha, beta, and gamma were significantly lower for epilepsy patients.
The C3-C4 electrode pair consistently showed reduced coherence across frequency bands for the epilepsy group.
Overall interhemispheric coherence was significantly lower in patients with severe generalized epilepsy compared to controls.