What is the clinical evidence from this study?

Study design: Review. Population: Cardiovascular diseases. Intervention: Estrogens.

What does this research mean for the field?

Estrogens have antiatherogenic effects that can be clinically utilized for the primary and secondary prevention of cardiovascular diseases in postmenopausal women, especially in the presence of cardiovascular risk factors. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The research aims to explore the effects of estrogens on cardiovascular disease in postmenopausal women.

February 12, 2026Cardiovascular Medicine0 citationsOpen Access

Einfluss der Östrogene auf Herz- und Kreislauf- Erkrankungen bei der Frau

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EWElizabeth C. WightMayo Clinic MBMatthias BartonPreventive Cardiology ZYZ. YangUniversity of Zurich

Key Result

Estrogens exhibit antiatherogenic and vasoactive effects that can be utilized for primary and secondary prophylaxis of cardiovascular diseases in postmenopausal women.

Key Points

The research aims to explore the effects of estrogens on cardiovascular disease in postmenopausal women.
Investigated the vasoactive properties of estrogens
Analyzed their impact on vascular smooth muscle
Evaluated the effects on lipid profiles and glucose metabolism
Considered the role of estrogens in mitigating cardiovascular risk factors
Estrogens promote vasodilation and inhibit platelet aggregation
They positively influence lipid profiles and glucose metabolism
Estrogens may help in preventing cardiovascular diseases in postmenopausal women with risk factors

Structured PICO

Do estrogens provide primary and secondary prophylaxis for cardiovascular diseases in postmenopausal women?

Population

Postmenopausal women, particularly those with cardiovascular risk factors

Intervention

Estrogens

Estrogens possess vasoactive and antiatherogenic properties that may be clinically useful for cardiovascular disease prevention in postmenopausal women.

Abstract

abstractOstrogene sind vasoaktive Substanzen. Sie bewirken eine Vasodilatation durch direkte und indirekte, d.h. endothelvermittelte, Einwirkungen auf die glatte Gefässmuskulatur, hemmen die Migration und Proliferation derselben, verhindern die Thrombozytenaggregation und blockieren die Oxidation von Low-density-Lipoprotein (LDL) durch ihre antioxidative Wirkung. Daneben beeinflussen sie insbesondere das Lipidprofil, den Glukosemetabolismus und andere Stoffwechselvorgänge günstig. Diese antiatherogenen Wirkungen können zur primären und sekundären Prophylaxe von HerzKreislauf-Erkrankungen bei der postmenopausalen Frau klinisch ausgenutzt werden, speziell wenn kardiovaskuläre Risikofaktoren vorliegen.

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Cite This Study

Wight et al. (Wed,) conducted a review in Cardiovascular diseases. Estrogens was evaluated. Estrogens exhibit antiatherogenic and vasoactive effects that can be utilized for primary and secondary prophylaxis of cardiovascular diseases in postmenopausal women.

synapsesocial.com/papers/698d6edc5be6419ac0d54c07 https://doi.org/https://doi.org/10.3390/cardiovascmed1040055

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