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February 12, 2026Journal of Biomedical Materials Research Part B Applied Biomaterials

In Vitro and In Vivo Evaluation of Polycaprolactone/Carboxymethyl Chitosan Composite 3D Scaffolds Loaded With Cerivastatin and 45S5 Bioglass Nanoparticles for Bone Tissue Engineering in Rat Calvarial Defects

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Authors

YAYasmin AlimardaniJahrom University of Medical SciencesMSMajid SalehiShahroud University of Medical SciencesAMAbdolvahab MoradiGolestan University

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Implication

In vitro and in vivo evaluations show improved bone regeneration with specific cerivastatin concentrations in rat calvarial defects, implying effective scaffold design.

Key Points

  • The research aims to evaluate the effectiveness of PCL/CMC scaffolds loaded with cerivastatin and bioglass nanoparticles for enhancing bone regeneration.
  • Fabricated scaffolds with varying cerivastatin concentrations using freeze-casting.
  • Conducted in vitro characterization including cytotoxicity and physical property tests.
  • Performed in vivo implantation of scaffolds into rat calvarial defects for 12 weeks.
  • Utilized histological analysis to assess bone and fibrous tissue formation.
  • Scaffolds showed good biocompatibility and optimal physical properties.
  • 0.1% cerivastatin significantly increased bone formation and osteon quantity (p < 0.05).
  • Higher cerivastatin concentrations (1%) resulted in decreased bone formation and increased fibrous tissue.
  • Scaffold degradation led to higher blood coagulation and acidity levels (p < 0.05).

Cite This Study

Alimardani et al. (2026) studied this question.

synapsesocial.com/papers/698d6eeb5be6419ac0d54eb4https://doi.org/10.1002/jbmb.70027
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