What question did this study set out to answer?

February 12, 2026Lupus

Phenotypic clustering of cardiovascular risk profiles in systemic lupus erythematosus

View Full Paper

Ask AI

Bookmark

Authors

Observational study identifies distinct cardiovascular risk phenotypes in systemic lupus erythematosus, suggesting tailored intervention strategies.

The study aims to identify distinct cardiovascular risk profiles in systemic lupus erythematosus (SLE) patients using clustering techniques.
Conducted a comprehensive cardiovascular risk assessment in SLE patients from a national referral center.
Utilized an unsupervised hierarchical clustering algorithm on clinical, biological, and imaging data.
Compared incident ASCVD rates, follow-up CAC scores, and CAC progression across identified clusters.
Identified three distinct clusters of cardiovascular risk profiles among 226 SLE patients.
Cluster 1 had young females with few risk factors, Cluster 2 had older females with high LDL and increased CAC, Cluster 3 included middle-aged patients with diabetes and higher CAC.
Significant differences in ASCVD event rates and CAC scores among the clusters (C3>C2>C1, all P < .01).

Azoulay et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark

Observational study identifies distinct cardiovascular risk phenotypes in systemic lupus erythematosus, suggesting tailored intervention strategies.