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February 12, 2026Journal of Evidence-Based Integrative MedicineOpen Access

Impact of Syndrome Differentiation on Treatment Effects and side Effects of Chinese Herbal Medicine in Randomized Controlled Trials: A Meta-Epidemiological Study

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Authors

CZClaire C.W. ZhongBWBetty Huan WangMJMary Yue Jiang

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Overview

Meta-epidemiological study evaluates treatment and side effects of Chinese herbal medicine with syndrome differentiation.

Key Points

  • To evaluate the effect of syndrome differentiation on treatment and side effects in Chinese herbal medicine RCTs.
  • Conducted a meta-epidemiological analysis of systematic reviews.
  • Identified 137 systematic reviews with 2,064 RCTs from seven databases.
  • Performed subgroup analyses based on disease category and outcome nature.
  • Observed small and statistically nonsignificant differences in treatment effects between RCTs with and without syndrome differentiation.
  • Subgroup analysis indicated a larger magnitude of side effects in gastrointestinal disease RCTs incorporating syndrome differentiation.
  • For circulatory diseases, syndrome differentiation was associated with a statistically significantly smaller treatment effect.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/698d6f0d5be6419ac0d551f9https://doi.org/10.1177/2515690x261422020
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