What question did this study set out to answer?

This investigation aims to evaluate the long-term outcomes and prognostic factors associated with repeated pulmonary metastasectomies.

February 12, 2026Annals of Surgical Oncology1 citationsOpen Access

Long-Term Results of Multiple Pulmonary Metastasectomies

MFMichele FerrariFondazione IRCCS Istituto Nazionale dei Tumori CVCamilla ValsecchiFondazione IRCCS Istituto Nazionale dei Tumori GLGiovanni LeuzziFondazione IRCCS Istituto Nazionale dei Tumori

Key Points

This investigation aims to evaluate the long-term outcomes and prognostic factors associated with repeated pulmonary metastasectomies.
Analyzed long-term results of 1503 pulmonary metastasectomies performed on 1106 patients.
Focused on multiple and repeated procedures, type of surgical resection, and prognostic factors.
Patients stratified into cohorts based on metastasis type: single, multiple, and recurrent.
Overall 10-year survival rate was 35.5%, with rates of 41.1% for single metastasis, 30.8% for multiple, and 31.1% for recurrent metastases.
Median survivals were 5.1 years overall, varying by cohort: 5.4 years (SM), 3.8 years (MM), and 5.9 years (RM).
Precision resection was the most common procedure, with 5-year survival at 54.0% and 10-year at 33.4%.
30-day postoperative mortality was very low at 0.1% overall.

Abstract

Abstract Background Pulmonary metastases affect up to 30% of cancer patients, but the incidence depends on the primary tumor type. Advances in therapy have expanded indications for pulmonary metastasectomy beyond highly selected cases. This study investigated long-term outcomes and prognostic factors of repeated pulmonary metastasectomies in modern clinical practice. Methods This study analyzed the long-term results of 1503 pulmonary metastasectomies performed on 1106 consecutive patients at the Istituto Nazionale Tumori of Milan between 2003 and 2018, with a focus on multiple and repeated procedures, type of surgical resection, and key prognostic factors. Patients were stratified into three cohorts: single metastasis (SM, n = 530), multiple metastases (MM, n = 595), and recurrent metastases (RM, n = 378). Results The 10 year survival rates were 35.5% overall, 41.1% for SM, 30.8% for MM, and 31.1% for RM. The median survivals were as 5.1, 5.4, 3.8, and 5.9 years respectively. Precision resection was the most common type of procedure (53.2%), with 54.0% survival at 5 years and 33.4% survival at 10 years. The 30 day postoperative mortality was 0.1% overall, 0% for SM, 0.3% for MM, and 0% for RM. Conclusions These findings highlight the feasibility and curative potential of multiple and repeated pulmonary metastasectomies for carefully selected patients.

Ask AI

Helpful

Bookmark

View Full Paper