Microvascular Genesis of Diseases: From Hypothesis to Theory

February 11, 2026LifeOpen Access

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Key Points

The research aims to redefine the understanding of disease pathogenesis by highlighting the significance of microvasculature damage in organ function.
Conducted a literature search in international databases for sources until December 2025.
Reviewed own studies published from 1989 to present as evidence.
Analyzed morphological studies on the role of microvessels in both infectious and non-infectious diseases.
Demonstrated that microvessels are primary targets for damage in early stages of diseases.
Revealed a cascade of cellular changes in parenchymal cells initiated by microvascular damage.
Proposed a new theoretical framework for understanding known disease processes.

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This article proposes a new theory on disease pathogenesis emphasizing microvasculature's critical role, suggesting innovative therapeutic avenues.

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Nasyrov et al. (2026) studied this question.

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