Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1997The Journal of General PhysiologyOpen Access

Molecular Analysis of the Putative Inactivation Particle in the Inactivation Gate of Brain Type IIA Na+ Channels

View Full Paper
Ask AI
Bookmark
Share

Key result

Mutations at F1489 and T1491 significantly destabilized the inactivated state of rat brain type IIA Na+ channels, impacting inactivation and recovery rates.

Population

Rat brain type IIA Na+ channels

Comparison

Mutations within and adjacent to hydrophobic… vs Unmutated/wild-type channels

Design

Preclinical

Authors

SKStephan KellenbergerUniversity of LausanneJWJames W. WestVanderbilt UniversityTSTodd ScheuerElectrophysiology

Discussion

Loading...

Member takes

Implication

Identifies key Na+ channel inactivation determinants; extends mechanistic models but leaves clinical translation open.

Structured PICO

P
Population
Rat brain type IIA Na+ channels
I
Intervention
Mutations within and adjacent to hydrophobic clusters in LIII-IV (e.g., F1489, T1491, YY1497/8)
C
Comparator
Unmutated/wild-type channels
O
Outcome
Fast Na+ channel inactivation (macroscopic and single channel currents)surrogate

The IFM hydrophobic cluster and adjacent T1491 are unique in contributing to the stability of the inactivated state of Na+ channels.

Cite This Study

Kellenberger et al. (1997) studied this question. Mutations at F1489 and T1491 significantly destabilized the inactivated state of rat brain type IIA Na+ channels, impacting inactivation and recovery rates.

synapsesocial.com/papers/698e338048ff5e2bc41f755dhttps://doi.org/10.1085/jgp.109.5.589
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Critical Role for Transmembrane Segment IVS6 of the Sodium Channel α Subunit in Fast Inactivation1995 · 175 citations
  2. 2Single-channel analysis of inactivation-defective rat skeletal muscle sodium channels containing the F1304Q mutation1996 · 24 citations
  3. 3Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro.1994 · 209 citations
  4. 4Inactivation viewed through single sodium channels.1984 · 163 citations
  5. 5Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation1990 · 1,553 citations