What does this research mean for the field?

The voltage dependence of macroscopic sodium channel inactivation is significantly driven by the voltage-dependent rate of inactivation from the open state, and this inherently voltage-dependent process does not necessarily produce a conspicuous gating current. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1984The Journal of General PhysiologyOpen Access

Inactivation viewed through single sodium channels.

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Population

Tissue-cultured GH3 cells

Design

Preclinical

Authors

CVC A VandenbergKaleida Health RHR HornZoological Society of San Diego

Discussion

Member takes

Implication

Does not inform clinical sodium channel management; extends basic understanding of voltage-dependent open-state inactivation.

Structured PICO

Population

Tissue-cultured GH3 cells

Intervention

Voltage depolarization and maximum likelihood analysis of single sodium channel records

Outcome

Voltage dependence of individual rate constants for sodium channel inactivationsurrogate

This basic science study demonstrates that the voltage dependence of sodium channel inactivation from the open state significantly contributes to macroscopic inactivation.

Cite This Study

Vandenberg et al. (1984) studied this question.

synapsesocial.com/papers/6a193cd6fa25ab5db6d944ff https://doi.org/10.1085/jgp.84.4.535

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Bookmark

Inactivation viewed through single sodium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inactivation viewed through single sodium channels.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider