Key result
In HEK 293 cells expressing the α1G channel, inactivation is state-dependent and allosterically coupled to the movement of the first three voltage sensors to activate.
Population
HEK 293 cells stably expressing the α1G channel
Design
Preclinical
Authors
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Advances T-type channel kinetic models; leaves open in vivo cardiac relevance.
The study demonstrates that α1G T-type calcium channels exhibit state-dependent inactivation allosterically coupled to voltage sensor movement, which causes cumulative inactivation during repetitive pulses.
Serrano et al. (1999) studied this question. Voltage depolarization was evaluated on Kinetics of whole-cell T-current. In HEK 293 cells expressing the α1G channel, inactivation is state-dependent and allosterically coupled to the movement of the first three voltage sensors to activate.
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