What question did this study set out to answer?

The aim is to highlight recent advancements in blood-based biomarkers for early Alzheimer's disease detection and monitoring.

February 13, 2026Ageing Research ReviewsOpen Access

Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration

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Authors

WFWenting FuKing's College London PHPaul Chi-Lui HoMonash University Malaysia

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Implication

This review demonstrates advances in blood biomarkers for early detection of Alzheimer's disease, suggesting transformative implications for aging populations.

Key Points

The aim is to highlight recent advancements in blood-based biomarkers for early Alzheimer's disease detection and monitoring.
Review of existing literature on blood-based biomarkers for Alzheimer's disease.
Evaluation of biomarkers including phosphorylated tau proteins, neurofilament light chain, and glial fibrillary acidic protein.
Assessment of the diagnostic accuracy of these biomarkers using advanced detection technologies.
Phosphorylated tau protein p-tau217 shows AUC values greater than 0.93 and a 91% positive predictive value for detecting AD.
Blood-based biomarkers can identify pathological changes up to 15-20 years before symptoms appear.
Plasma p-tau217 levels increase by over 8.5% annually during preclinical stages.

Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93015fc8 https://doi.org/10.1016/j.arr.2026.103058

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Implication

This review demonstrates advances in blood biomarkers for early detection of Alzheimer's disease, suggesting transformative implications for aging populations.

Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration

Discussion

Member takes

Implication

Key Points

Cite This Study

Blood-based biomarkers for Alzheimer's disease: Advances in early detection and monitoring of age-related neurodegeneration

Discussion

Member takes

Implication

Key Points

Cite This Study

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