What question did this study set out to answer?

To investigate the detection rates of clinically significant prostate cancer in Black men with PI-RADS 3 lesions during targeted biopsy.

February 13, 2026Urologic Oncology Seminars and Original Investigations0 citationsOpen Access

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Not all PI-RADS 3 lesions are the same: Higher rate of clinically significant prostate cancer among Black men on targeted biopsy in a diverse cohort

DHDavid G. HanelinAlbert Einstein College of Medicine PDPriya DaveMontefiore Medical Center ABAndrewe BacaMontefiore Medical Center

Key Points

To investigate the detection rates of clinically significant prostate cancer in Black men with PI-RADS 3 lesions during targeted biopsy.
Analyzed data from a diverse cohort of men undergoing targeted biopsy for PI-RADS 3 lesions.
Conducted comparisons of clinically significant prostate cancer detection rates between racial groups.
Utilized MRI to assess phenotypic appearance of lesions.
Black men had significantly higher odds of detecting clinically significant prostate cancer on targeted biopsy.
Data supports that MRI appearance of prostate cancer varies across different races.
Findings may influence risk stratification and management of prostate cancer in diverse populations.

Abstract

NHB had significantly higher odds of csPCa detection on targeted biopsy of PI-RADS 3 lesions. These findings support emerging data that phenotypic appearance of prostate cancer on MRI differs by race and may be relevant for risk stratification and management counseling of PI-RADS 3 lesions.

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Cite This Study

Hanelin et al. (Mon,) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93016026 https://doi.org/https://doi.org/10.1016/j.urolonc.2026.110995

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