Classifying Parkinson’s Disease Progression via Latent Trajectories of Striatal Specific Binding Ratios from I-123 FP-CIT SPECT in Association with Levodopa-Induced Dyskinesia

Kee Yeun Lee; Eun Hye Jeong; Won‐Woo Lee; Yoo Sung Song

doi:10.3174/ajnr.a9213

February 10, 2026American Journal of NeuroradiologyOpen Access

Classifying Parkinson’s Disease Progression via Latent Trajectories of Striatal Specific Binding Ratios from I-123 FP-CIT SPECT in Association with Levodopa-Induced Dyskinesia

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Key Points

The aim is to classify the progression of Parkinson’s disease by analyzing imaging trajectories and their relationship with levodopa-induced dyskinesia.
Conducted longitudinal imaging using I-123 FP-CIT SPECT.
Analyzed striatal specific binding ratios over time.
Integrated clinical characteristics with imaging data.
Found contemporaneous associations between imaging data and LID occurrence.
Identified potential clinically relevant insights for disease progression classification.

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Implication

Longitudinal imaging trajectories demonstrate dyskinesia associations in Parkinson’s Disease, suggesting diagnostic advancements.

Abstract

Longitudinal imaging trajectories demonstrate contemporaneous associations with LID occurrence in PD and may provide clinically relevant insights when combined with clinical characteristics.

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93016112 https://doi.org/10.3174/ajnr.a9213

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Classifying Parkinson’s Disease Progression via Latent Trajectories of Striatal Specific Binding Ratios from I-123 FP-CIT SPECT in Association with Levodopa-Induced Dyskinesia

Key Points

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Implication

Abstract

Discussion

Cite This Study

Classifying Parkinson’s Disease Progression via Latent Trajectories of Striatal Specific Binding Ratios from I-123 FP-CIT SPECT in Association with Levodopa-Induced Dyskinesia

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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