Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs

Zehra Babayigit; Ayşe Pelin Yiğider; Özgür Yiğit; Arzu Gedik; Şeyma Dümür; Hafize Uzun

doi:10.1080/00016489.2025.2600090

February 10, 2026Acta Oto-Laryngologica

Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs

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Key Points

The study aims to evaluate the effects of N-acetylcystein in reducing vestibulotoxicity induced by gentamicin.
Used a guinea pig model for vestibulotoxicity via gentamicin administration.
Administered intratympanic N-acetylcystein as a potential protective agent.
Measured c-VEMP responses and assessed oxidative capacity in tissue and serum.
Gentamicin caused a significant loss in c-VEMP responses.
N-acetylcystein effectively reduced the loss of c-VEMP responses.
Oxidative capacity measurements confirmed the protective role of NAC at tissue and serum levels.

Implication

Experimental study shows N-acetylcystein reduces vestibulotoxicity in guinea pigs, suggesting a potential protective treatment.

Abstract

Gentamicin induced loss in c-VEMP responses and NAC played an effective role in reducing this loss which were confirmed by oxidative capacity at tissue and serum level.

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Cite This Study

Babayigit et al. (2026) studied this question.

synapsesocial.com/papers/698ebeb185a1ff6a93016184 https://doi.org/10.1080/00016489.2025.2600090

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Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs

Key Points

Implication

Abstract

Discussion

Cite This Study

Effect of intratympanic N-acetylcystein (NAC) on vestibulotoxicity model formed with intratympanic gentamicin in Guinea pigs

Key Points

Implication

Abstract

Discussion

Cite This Study

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