Diagnostic accuracy of venous manometry to predict elevated intracranial pressure

Background and purpose Venous sinus stenting (VSS) is a well-established treatment for idiopathic intracranial hypertension (IIH). Diagnostic workup includes lumbar puncture (LP) for intracranial pressure (ICP) measurement and catheter venography with manometry to assess venous sinus stenosis. We evaluated the diagnostic accuracy of venous manometry in predicting elevated ICP. Materials and methods We retrospectively reviewed patients with venous sinus stenosis who underwent catheter cerebral venography with venous pressure (mmHg) recording and fluoroscopy-guided LP with cerebrospinal fluid opening pressure (CSF-OP, cmH₂O) measurement during the same session. Elevated ICP was defined as CSF-OP ≥20 cmH₂O. Linear regression assessed relationships between venous pressures, trans-stenotic gradient (TSG), and CSF-OP. Sensitivity, specificity, and receiver operating characteristic (ROC) analyses were performed. Results 84 female patients (mean age 35.5 years) with ≥50% stenosis of the dominant or codominant lateral venous sinuses were included. TSG demonstrated the strongest correlation with CSF-OP (adjusted R 2 = 0.57, p 0.05), followed by superior sagittal sinus (SSS) pressure (adjusted R 2 = 0.53, p 0.05). ROC analysis showed areas under the curve of 0.87 for TSG, 0.84 for SSS pressure, and 0.94 when combined. Optimal thresholds were SSS pressure ≥15 mmHg (sensitivity 0.88, specificity 0.68) and TSG ≥ 6 mmHg (sensitivity 0.86, specificity 0.80). In patients with TSG ≥ 6 mmHg, an SSS threshold of 15 mmHg yielded sensitivity 0.94 and specificity 0.85. Conclusion SSS pressure and TSG strongly predict ICP elevation in venous sinus stenosis, with combined thresholds providing the highest diagnostic accuracy.